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A signature of platelet reactivity in CBC scattergrams reveals genetic predictors of thrombotic disease risk

2023-07-27

Abstract excerpt

Genetic studies of platelet reactivity (PR) phenotypes may identify novel antiplatelet drug targets. However, discoveries have been limited by small sample sizes ( n <5,000) due to the complexity of measuring PR. We trained a model to predict PR from complete blood count (CBC) scattergrams. A GWAS of this phenotype in 29,806 blood donors identified 21 distinct associations implicating 20 genes, of which six have b...

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Literature Corpus work
7ec845b6-dee4-5d84-b70e-f3b0a9962cd8
DOI
10.1101/2023.07.26.23293204
Open publication

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A signature of platelet reactivity in CBC scattergrams reveals genetic predictors of thrombotic disease riskDOI 10.1101/2023.07.26.23293204
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