Article

Systematic analysis of RNAi-accessible SARS-CoV-2 replication steps identifies ORF1 as promising target

2020-12-01

Abstract excerpt

<title>Abstract</title> <p>A promising approach to tackle the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) could be small interfering (si)RNAs. The proof of concept that SARS-CoV-2 can be inhibited with siRNAs, however, is missing. Here, we report that siRNAs can target genomic RNA (gRNA) of SARS-CoV-2 after cell entry, terminating replication before start of transcription and preventing cytopathi...

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Identifiers and source

Literature Corpus work: 624779a6-a194-5702-a58d-9c8688cfdee3
DOI: 10.21203/rs.3.rs-105129/v2

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