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Article

Selection and Validation of siRNAs Preventing Uptake and Replication of SARS-CoV-2

2 Mar 2022

Abstract excerpt

In 2019, the novel highly infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak rapidly led to a global pandemic with more than 346 million confirmed cases worldwide, resulting in 5.5 million associated deaths (January 2022). Entry of all SARS-CoV-2 variants is mediated by the cellular angisin-converting enzyme 2 (ACE2). The virus abundantly replicates in the epithelia of the upper...

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Identifiers

PMID: 35309990
DOI: 10.3389/fbioe.2022.801870

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