Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of SARS-CoV-2 Replication by a Small Interfering RNA Targeting the Leader Sequence

8 Oct 2021

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected almost 200 million people worldwide and led to approximately 4 million deaths as of August 2021. Despite successful vaccine development, treatment options are limited. A promising strategy to specifically target viral infections is to suppress viral replication through RNA interference (RNAi). Hence, we designed eight small interfering RNAs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced biosensing and bioanalysis techniques
Share to RNA Interference and Gene Delivery
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34696460
DOI: 10.3390/v13102030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of SARS-CoV-2 Replication by a Small Interfering RNA Targeting the Leader SequencePMID 34696460Read ↗

In Silico and In Vitro Development of novel small interfering RNAs (siRNAs) to inhibit SARS-CoV-2Semantic proximity Read ↗

Novel siRNA therapeutics demonstrate multi-variant efficacy against SARS-CoV-2Semantic proximity Read ↗

Selection and Validation of siRNAs Preventing Uptake and Replication of SARS-CoV-2Semantic proximity Read ↗

In Silico and In Vitro development of novel small interfering RNAs (siRNAs) to inhibit SARS-CoV-2Semantic proximity Read ↗

Structural and Functional RNA Motifs of SARS-CoV-2 and Influenza A Virus as a Target of Viral InhibitorsSemantic proximity Read ↗

siRNA targeting the Leader sequence of SARS-CoV inhibits virus replicationSemantic proximity Read ↗

The Potential Therapeutic Effect of RNA Interference and Natural Products on COVID-19: A Review of the Coronaviruses InfectionSemantic proximity Read ↗

Inhibition of SARS-Associated Coronavirus Infection and Replication by RNA InterferenceSemantic proximity Read ↗

Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spreadSemantic proximity Read ↗

A small interfering RNA (siRNA) database for SARS-CoV-2Semantic proximity Read ↗

Systematic analysis of RNAi-accessible SARS-CoV-2 replication steps identifies ORF1 as promising targetSemantic proximity Read ↗

siRNA Therapeutics for the Therapy of COVID-19 and Other Coronaviruses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.