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Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread

5 Dec 2021

Abstract excerpt

A promising approach to tackle the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) could be small interfering (si)RNAs. So far it is unclear, which viral replication steps can be efficiently inhibited with siRNAs. Here, we report that siRNAs can target genomic RNA (gRNA) of SARS-CoV-2 after cell entry, and thereby terminate replication before start of transcription and prevent virus-induced cell...

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Share to Advanced biosensing and bioanalysis techniques
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PMID: 34928377
DOI: 10.1093/nar/gkab1248

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