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In Silico and In Vitro development of novel small interfering RNAs (siRNAs) to inhibit SARS-CoV-2

1 Jan 2025

Abstract excerpt

SARS-CoV-2 is causing severe to moderate respiratory tract infections, posing global health, social life, and economic threats. Our design strategy for siRNAs differs from existing studies through a step-by-step filtration process utilizing integrative bioinformatics protocols and web tools. Stage one: Multiple Sequence Alignment was employed to identify the most conserved areas. Stage two involves using various...

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PMID: 40256168
DOI: 10.1016/j.csbj.2025.03.034

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