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CircRNA-based, non-integrated, <i>in vivo</i> panCAR-mediated B cell immune resetting in mouse models and non-human primates

2025-08-11

Abstract excerpt

<h4>SUMMARY</h4> B cell immune resetting, defined as the comprehensive depletion and subsequent reconstitution of B cells, represents a pivotal therapeutic approach for B cell-associated disorders. Recently, chimeric antigen receptor T cell (CAR-T) therapy has demonstrated substantial clinical efficacy in treating B cell malignancies and autoimmune diseases. However, this approach remains constrained by its relia...

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Literature Corpus work
623f9d5f-663a-506d-99c8-80d340708247
DOI
10.1101/2025.08.11.669448
Open publication

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CircRNA-based, non-integrated, <i>in vivo</i> panCAR-mediated B cell immune resetting in mouse models and non-human primatesDOI 10.1101/2025.08.11.669448
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