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Article

Scarless circular mRNA-based CAR-T cell therapy elicits superior anti-tumor efficacy

2024-08-05

Abstract excerpt

Messenger RNA (mRNA)-based transient expression of CAR shows optimal safety profiles and provides promising opportunities to address existing challenges of viral vector-based CAR-T therapies and to meet emerging medical needs in noncancerous indications. However, linear mRNAs are intrinsically unstable and thus just achieve compromised efficacy. Here, we engineered a permuted intron exon (PIE) platform to synthesi...

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Identifiers and source

Literature Corpus work
c02bbc2d-e325-57bf-9ac0-6c457e1abac5
DOI
10.1101/2024.08.05.606578
Open publication

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Scarless circular mRNA-based CAR-T cell therapy elicits superior anti-tumor efficacyDOI 10.1101/2024.08.05.606578
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