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Manufacturing CD20/CD19-targeted iCasp9 regulatable CAR-T <sub>SCM</sub> cells using <i>qCART</i> , the <i>Quantum pBac</i> -based CAR-T system

2022-05-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> CD19-targeted chimeric antigen receptor therapies (CAR19) have driven a paradigm shift in the treatment of relapsed/refractory B-cell malignancies. However, >50% of CAR19-treated patients experienced progressive disease mainly due to antigen escape and low persistence. Clinical prognosis is heavily influenced by CAR-T cell function and systemic cytokine toxicities. Furthermo...

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Literature Corpus work
5e1b56a0-a130-5a67-865a-4215023650e9
DOI
10.1101/2022.05.03.490475
Open publication

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Manufacturing CD20/CD19-targeted iCasp9 regulatable CAR-T <sub>SCM</sub> cells using <i>qCART</i> , the <i>Quantum pBac</i> -based CAR-T systemDOI 10.1101/2022.05.03.490475
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