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RNA Therapeutics for Improving CAR T-cell Safety and Efficacy

13 Dec 2022

Abstract excerpt

Autologous chimeric antigen receptor (CAR) T cells have recently emerged as potent tools in the fight against cancer, with promising therapeutic efficacy against hematological malignancies. However, several limitations hamper their widespread clinical use, including availability of target antigen, severe toxic effects, primary and secondary resistance, heterogeneous quality of autologous T cells, variable...

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PMID: 36512627
DOI: 10.1158/0008-5472.can-22-2155

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