Article

Targeting VPS35-ZNT1 Interaction by Engeletin Prevents Zinc Overload and Alleviates Myocardial Ischemia-Reperfusion Injury via Surface ZNT1 Stabilization

2026-04-22

Abstract excerpt

<title>Abstract</title> Myocardial ischemia-reperfusion (I/R) injury remains a critical clinical challenge, driven by unresolved inflammation and oxidative stress. This study investigated the cardioprotective effects of engeletin (ENG), a flavonoid glycoside, in mitigating myocardial I/R injury through modulation of zinc and redox homeostasis. In a murine I/R model, ENG administration significantly improved ca...

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Literature Corpus work: 62393e2a-7986-516a-ac98-e5a08728cb03
DOI: 10.21203/rs.3.rs-9229364/v1

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Targeting VPS35-ZNT1 Interaction by Engeletin Prevents Zinc Overload and Alleviates Myocardial Ischemia-Reperfusion Injury via Surface ZNT1 StabilizationDOI 10.21203/rs.3.rs-9229364/v1Read

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