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Cyclic azapeptide cluster of differentiation-36 receptor modulator attenuates left ventricular injury and temporarily reduces long-chain fatty acid accumulation after myocardial ischemia-reperfusion in mice

2025-09-09

Abstract excerpt

Ischemic heart disease remains a leading global cause of death. We investigated the cardio-protective effects of the selective cluster of differentiation-36 receptor (CD36) modulator azapeptide MPE-298 in a mouse model of myocardial ischemia-reperfusion. Before reperfusion, a single intravenous dose of azapeptide MPE-298 reduced infarct size by 37% and transiently decreased left ventricular (LV) long-chain fatty a...

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Literature Corpus work
45338212-ad7b-51e1-bb77-01627ea0965e
DOI
10.1101/2025.09.04.674351
Open publication

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Cyclic azapeptide cluster of differentiation-36 receptor modulator attenuates left ventricular injury and temporarily reduces long-chain fatty acid accumulation after myocardial ischemia-reperfusion in miceDOI 10.1101/2025.09.04.674351
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