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Zinc <sup>2+</sup> ion inhibits SARS-CoV-2 main protease and viral replication <i>in vitro</i>

2021-06-15

Abstract excerpt

Zinc deficiency is linked to poor prognosis in COVID-19 patients while clinical trials with Zinc demonstrate better clinical outcome. The molecular target and mechanistic details of anti-coronaviral activity of Zinc remain obscure. We show that ionic Zinc not only inhibits SARS-CoV-2 main protease (Mpro) with nanomolar affinity, but also viral replication. We present the first crystal structure of Mpro-Zn 2+ comp...

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Identifiers and source

Literature Corpus work
81cd5f6c-a00b-5c82-af60-fefe39db5869
DOI
10.1101/2021.06.15.448551
Open publication

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Zinc <sup>2+</sup> ion inhibits SARS-CoV-2 main protease and viral replication <i>in vitro</i>DOI 10.1101/2021.06.15.448551
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