Article

Quercetin activates the SIRT6-Nrf2 axis during oxidative stress, modulating ageing-associated markers in healthy men

2025-11-02

Abstract excerpt

Quercetin is a dietary flavonoid with antioxidant, anti-inflammatory, and senolytic properties, yet its effects on exercise-induced DNA damage responses in healthy humans are unclear. We conducted a double-blind, placebo-controlled crossover trial (n = 13, middle-aged men) combining acute high-intensity interval exercise (HIIE) with 21-day quercetin supplementation (1000 mg/day). We quantified plasma quercetin and...

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Literature Corpus work: 4df1fb04-b6e5-508c-b07c-3bcf78c03ce8
DOI: 10.1101/2025.10.31.25338366

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