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Angelica sinensis Polysaccharide nanoparticles can improve myocardial ischemia-reperfusion injury by inhibiting ferritinophagy via the ATF6/NCOA4 pathway

2025-08-11

Abstract excerpt

<title>Abstract</title> <p>Background Ferroptosis aggravates myocardial ischemia-reperfusion injury (MI/RI) by disrupting iron homeostasis, accelerating lipid peroxidation, and elevating reactive oxygen species (ROS) levels. Although Angelica sinensis polysaccharide (ASP) has shown protective effects against MI/RI, its clinical translation remains limited due to poor bioavailability and low target specificity. Me...

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Literature Corpus work
036aeb12-fb56-510a-81a2-0363814ed6a5
DOI
10.21203/rs.3.rs-7142720/v1
Open publication

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