Article

Penalised neural network with weight correlation descent for predicting polygenic risk score

2023-05-28

Abstract excerpt

In this study, we developed a deep neural network (DNN) model with weight correlation descent (WCD) regularization to improve polygenic risk score predictions for complex diseases, specifically gender-specific cancers, using the UK Biobank dataset. Our DNN model with WCD outperformed both conventional PRS models and DNN models without WCD, demonstrating the importance of regularization techniques in enhancing mode...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1797f5a0-bc92-5bf0-ae9e-b8310c6256d8
DOI: 10.1101/2023.05.23.23290438

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Penalised neural network with weight correlation descent for predicting polygenic risk scoreDOI 10.1101/2023.05.23.23290438Read

Deep Learning for Polygenic Risk PredictionSemantic proximity Read

Stacked neural network for predicting polygenic risk score.Semantic proximity Read

PRANA: A Deep Learning Method for Adapting Polygenic Risk Scores to Diverse Ethnic GroupsSemantic proximity Read

A Deep Learning-based Genome-wide Polygenic Risk Score for Common Diseases Identifies Individuals with RiskSemantic proximity Read

A Deep Ensemble Encoder Network Method for Improved Polygenic Risk Score PredictionSemantic proximity Read

Deep learning for polygenic prediction: The role of heritability, interaction type and sample sizeSemantic proximity Read

Performance of deep-learning based approaches to improve polygenic scoresSemantic proximity Read

Polygenic prediction of phenotypes with a neural empirical Bayes approachSemantic proximity Read

Deep Learning Framework for Complex Disease Risk Prediction Using Genomic Variations.Semantic proximity Read

Deep neural network improves the estimation of polygenic risk scores for breast cancer.Semantic proximity Read

DROP-DEEP: Dimensionality Reduction for Polygenic Risk Score Using Deep Learning ApproachSemantic proximity Read

Multimodal deep learning enhances genomic risk prediction for cardiometabolic diseases in UK BiobankSemantic proximity Read