Article

Drebrin forms a cortical hub that connects actin, microtubules, and clathrin for endocytic transport of β2 integrin

2026-03-13

Abstract excerpt

Using primary human macrophages, we analyze the molecular machinery that enables direct contact of microtubule +tips with podosomes, and its connection to clathrin-based endocytosis. We show that the podosome cap protein drebrin, together with its +tip-localized binding partner EB3, regulates podosome-microtubule contact. Importantly, drebrin depletion leads to reduced endocytosis, particularly of β2 integrin at p...

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Literature Corpus work: 621ef8b5-64b0-524a-9aa9-3c41eb1e18b1
DOI: 10.64898/2026.03.12.711275

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