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Article

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration

16 Jul 2025

Abstract excerpt

Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different cancers. The roles of EPLIN isoforms (α/β) remain largely unknown and could explain these opposing views. We observed distinct EPLIN isoform localization in breast cancer cells; EPLINα is recruited to actin in plasma membrane ruffles and endosomes, while EPLINβ...

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Identifiers

PMID: 40669465
DOI: 10.1016/j.devcel.2025.06.025

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