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Article

The role of disabled-2 (Dab2) in diseases

12 Oct 2020

Abstract excerpt

Disabled-2 (Dab2/DOC-2) is a mitogen-responsive adaptor protein required for multiple cellular functions. It is involved in many signaling pathways and plays an integral role in vesicular uptake and trafficking, modulating immune function, protein-protein interactions, cellular homeostasis and differentiation, oncogenesis, and inflammatory processes in organ systems. It contains domains for binding to NPXY...

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PMID: 33059028
DOI: 10.1016/j.gene.2020.145202

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