Article

Recapitulating the frataxin activation mechanism in an engineered bacterial cysteine desulfurase supports the architectural switch model

2020-10-06

Abstract excerpt

<h4>ABSTRACT</h4> Iron-sulfur (Fe-S) clusters have a key role in many biochemical processes and are essential for most life forms. Despite recent mechanistic advances in understanding the Fe-S cluster biosynthetic pathway, critical questions remain unresolved. Although human NFS1 and E. coli IscS share ∼60% sequence identity, NFS1 exhibits low activity and requires activation by the Friedreich’s ataxia protein f...

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Literature Corpus work: 28378317-c7d8-55e0-9633-26d63169cdc4
DOI: 10.1101/2020.10.06.326603

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