Article

Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism

2019-02-28

Abstract excerpt

Iron-sulfur clusters (ISC) are essential in all life forms and carry out many crucial cellular functions. The core machinery for de novo ISC biosynthesis, located in the mitochondria matrix, is a five-protein complex containing the cysteine desulfurase NFS1 that is activated by frataxin (FXN), scaffold protein ISCU, accessory protein ISD11, and acyl-carrier protein ACP. Deficiency in FXN leads to the loss-of-func...

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Literature Corpus work: 89ba4903-2759-5a2c-8dc0-5bcb6c5f5663
DOI: 10.1101/561795

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