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Article

Structural bases for the interaction of frataxin with the central components of iron-sulphur cluster assembly.

Nature communications - 19 Oct 2010

Prischi Filippo, Konarev Petr V, Iannuzzi Clara, Pastore Chiara, Adinolfi Salvatore, Martin Stephen R, Svergun Dmitri I, Pastore Annalisa

Abstract excerpt

Reduced levels of frataxin, an essential protein of as yet unknown function, are responsible for causing the neurodegenerative pathology Friedreich's ataxia. Independent reports have linked frataxin to iron-sulphur cluster assembly through interactions with the two central components of this machinery: desulphurase Nfs1/IscS and the scaffold protein Isu/IscU. In this study, we use a combination of biophysical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20981023
DOI: 10.1038/ncomms1097
PMCID: PMC2982165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural bases for the interaction of frataxin with the central components of iron-sulphur cluster assembly.PMID 20981023Read ↗

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