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Article

Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease.

Biochemistry - 22 Jun 2010

Ye Hong, Rouault Tracey A

Abstract excerpt

Iron-sulfur (Fe-S) proteins contain prosthetic groups consisting of two or more iron atoms bridged by sulfur ligands, which facilitate multiple functions, including redox activity, enzymatic function, and maintenance of structural integrity. More than 20 proteins are involved in the biosynthesis of iron-sulfur clusters in eukaryotes. Defective Fe-S cluster synthesis not only affects activities of many iron-sulfur...

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Source

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Identifiers

PMID: 20481466
DOI: 10.1021/bi1004798
PMCID: PMC2885827

Genes

ABCB7
ISCU
GLRX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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