Article

Molecular determinants of TRAF6 binding specificity suggest that native interaction partners are not optimized for affinity

2022-05-08

Abstract excerpt

<h4>ABSTRACT</h4> TRAF6 is an adapter protein and E3 ubiquitin ligase involved in signaling downstream of cell receptors essential for development and the immune system. TRAF6 participates in many protein-protein interactions, some of which are mediated by a C-terminal MATH domain that recruits TRAF6 to cell-surface receptors and associated proteins. The TRAF6 MATH domain binds to short peptide segments containin...

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Literature Corpus work: 61c7fe8e-6828-5a85-a0d1-455ff1632df5
DOI: 10.1101/2022.05.08.491058

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