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Article

Distinct molecular mechanism for initiating TRAF6 signalling.

Nature - 25 Jul 2002

Ye Hong, Arron Joseph R, Lamothe Betty, Cirilli Maurizio, Kobayashi Takashi, Shevde Nirupama K, Segal Deena, Dzivenu Oki K, Vologodskaia Masha, Yim Mijung, Du Khoi, Singh Sujay, Pike J Wesley, Darnay Bryant G, Choi Yongwon, Wu Hao

Abstract excerpt

Tumour-necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is the only TRAF family member that participates in signal transduction of both the TNF receptor (TNFR) superfamily and the interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily; it is important for adaptive immunity, innate immunity and bone homeostasis. Here we report crystal structures of TRAF6, alone and in complex with...

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Topics

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Share to CD40 Antigens
Share to Interleukin-1 Receptor-Associated Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Monocytes

Share to Osteoclasts

Share to Receptor Activator of Nuclear Factor-kappa B

Share to Receptors, Tumor Necrosis Factor

Share to TNF Receptor-Associated Factor 2

Share to TNF Receptor-Associated Factor 6

Source

Identifiers

PMID: 12140561
DOI: 10.1038/nature00888

Genes

TRAF6
TNF
TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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