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Article

Solid-Phase Parallel Synthesis of Photocleavable Bifunctional Molecules Enables Efficient Phenotypic Protein Degrader Discovery.

Angewandte Chemie (International ed. in English) - 28 Jul 2025

Ding Baoli, Hu Jiawen, Zhang Rongtian, Shou Binyan, Chen Mengdie, Jiang Li, Yuan Meng, Yang Bo, He Qiaojun, Cao Ji, Zhu Cheng-Liang

Abstract excerpt

Phenotypic screening offers an effective path for discovering protein degraders, particularly targeting proteins that are poorly characterized or lack sufficient ligand-binding information. Nonetheless, phenotypic protein degrader discovery (PPDD) faces practical hurdles, such as synthetic complexity in generating chemically diverse libraries and difficulties in reliably identifying degradation-driven phenotypes...

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PMID: 40432221
DOI: 10.1002/anie.202424118

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GSPT1

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