Article

Engineering single pan-specific ubiquibodies for targeted degradation of all forms of endogenous ERK protein kinase

2021-04-17

Abstract excerpt

Ubiquibodies (uAbs) are a customizable proteome editing technology that utilizes E3 ubiquitin ligases genetically fused to synthetic binding proteins to steer otherwise stable proteins of interest (POIs) to the proteasome for degradation. The ability of engineered uAbs to accelerate the turnover of exogenous or endogenous POIs in a posttranslational manner offers a simple yet robust tool for dissecting diverse fun...

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Literature Corpus work: 020c8560-5247-521d-befc-ad7753b05d7f
DOI: 10.1101/2021.04.16.440242

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