Article

Mecp2 deficiency impairs microscale cortical network topology and dynamics in a Rett syndrome mouse model

2025-12-19

Abstract excerpt

<h4>Summary</h4> Rett syndrome is a debilitating neurodevelopmental disorder with cerebral processing impairments caused by MECP2 loss-of-function mutations. Mecp2-deficient mouse models reveal disruptions of microscale cortical circuits. Yet how cellular-scale information processing is altered in Mecp2-deficient microscale functional networks is unknown. We investigated the development of functional connectivit...

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Literature Corpus work: 68835c91-6631-5a4c-933d-52e6c0fc9f19
DOI: 10.64898/2025.12.17.694950

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