Article
Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors.
Oncotarget - 22 Sept 2015
Colbeck Emily J, Hindley James P, Smart Kathryn, Jones Emma, Bloom Anja, Bridgeman Hayley, McPherson Rhoanne C, Turner Darryl G, Ladell Kristin, Price David A, O'Connor Richard A, Anderton Stephen M, Godkin Andrew J, Gallimore Awen M
Abstract excerpt
Foxp3(+) regulatory T cells (Tregs) are often highly enriched within the tumor-infiltrating T cell pool. Using a well-characterised model of carcinogen-induced fibrosarcomas we show that the enriched tumor-infiltrating Treg population comprises largely of CXCR3(+) T-bet(+) 'TH1-like' Tregs which are thymus-derived Helios(+) cells. Whilst IL-2 maintains homeostatic ratios of Tregs in lymphoid organs, we found that...
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