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Alternative lengthening of telomeres is not synonymous with mutations in ATRX/DAXX

10 Mar 2021

Abstract excerpt

The PCAWG Consortium has recently released an integrative re-analysis of a large set of tumor whole genome sequence (WGS) data from 2658 cancer patients across 38 different primary tumor sites 1 . In a companion paper, Sieverling et al. built a random forest classifier for the telomere maintenance mechanism (TMM) by regarding truncating ATRX or DAXX alterations, referred to as ATRX/DAXX trunc , vs. TERT...

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PMID: 33692341
DOI: 10.1038/s41467-021-21794-0

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