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A cortical immune network map identifies a subset of human microglia involved in Tau pathology

2017-12-14

Abstract excerpt

Microglial dysfunction has been proposed as one of the many cellular mechanisms that can contribute to the development of Alzheimer's disease (AD). Here, using a transcriptional network map of the human frontal cortex, we identify five gene modules of co-expressed genes related to microglia and assess their role in the neuropathologic features of AD in 541 subjects from two cohort studies of brain aging. Two of th...

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Literature Corpus work
618a47a1-45e4-5f90-86ba-00dfeff624fe
DOI
10.1101/234351
Open publication

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A cortical immune network map identifies a subset of human microglia involved in Tau pathologyDOI 10.1101/234351
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