Article
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
Nature cell biology - 1 Mar 2010
Komatsu Masaaki, Kurokawa Hirofumi, Waguri Satoshi, Taguchi Keiko, Kobayashi Akira, Ichimura Yoshinobu, Sou Yu-Shin, Ueno Izumi, Sakamoto Ayako, Tong Kit I, Kim Mihee, Nishito Yasumasa, Iemura Shun-ichiro, Natsume Tohru, Ueno Takashi, Kominami Eiki, Motohashi Hozumi, Tanaka Keiji, Yamamoto Masayuki
Abstract excerpt
Impaired selective turnover of p62 by autophagy causes severe liver injury accompanied by the formation of p62-positive inclusions and upregulation of detoxifying enzymes. These phenotypes correspond closely to the pathological conditions seen in human liver diseases, including alcoholic hepatitis and hepatocellular carcinoma. However, the molecular mechanisms and pathophysiological processes in these events are...
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