Article

Lymphotoxin <i>-</i> β Promotes Bone Colonization and Osteolytic Outgrowth of Indolent Bone Metastatic cells of Breast Cancer

2023-08-16

Abstract excerpt

<h4>SUMMARY</h4> Bone metastatic relapse is a lethal consequence of breast cancer, occurring years after initial diagnosis. By analyzing single-cell transcriptomes of bone-seeding tumor cells and in vivo barcoded cDNA library screening, LTβ (lymphotoxin-β) is identified as a key factor highly expressed in early-stage bone metastatic cells, associated with poor bone metastasis-free survival, and capable of promot...

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Literature Corpus work: 617ddcea-17a6-568c-b6b2-2a363e17df40
DOI: 10.1101/2023.08.15.553179

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