Article
Dormant tumor cells expressing LOXL2 acquire a stem-like phenotype mediating their transition to proliferative growth.
Oncotarget - 1 Nov 2016
Weidenfeld Keren, Schif-Zuck Sagi, Abu-Tayeh Hanan, Kang Keunsoo, Kessler Ofra, Weissmann Marina, Neufeld Gera, Barkan Dalit
Abstract excerpt
Recurrence of breast cancer disease years after treatment appears to arise from disseminated dormant tumor cells (DTC). The mechanisms underlying the outgrowth of DTC remain largely unknown. Here we demonstrate that dormant MCF-7 cells expressing LOXL2 acquire a cancer stem cell (CSC)-like phenotype, mediating their outgrowth in the 3D BME system that models tumor dormancy and outgrowth. Similarly, MCF-7-LOXL2...
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