Article

Enforced ZFP281 expression delays breast cancer initiation and can provide lifelong protection against breast cancer metastasis

2026-04-15

Abstract excerpt

<h4>ABSTRACT</h4> Breast cancer metastatic reactivation and its links to mammary development are largely unknown. Here, using conditional knockout and overexpression in normal and HER2+ mammary glands, we show that the dormancy regulator ZFP281 promotes branching and dissemination while suppressing growth, and its overexpression can even override HER2-driven cancer initiation. Notably, while ZFP281 does not limit...

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Literature Corpus work: 7f292105-af0e-5491-95dd-c4af9745c76f
DOI: 10.64898/2026.04.13.718280

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