Article

Nephronophthisis-associated FBW7 mediates cyst-dependent decline of renal function in ADPKD

2024-03-03

Abstract excerpt

<h4>ABSTRACT</h4> Nephronophthisis (NPHP) and autosomal dominant Polycystic Kidney Disease (ADPKD) are two genetically distinct forms of Polycystic Kidney Disease (PKD), yet both diseases present with kidney cysts and a gradual decline in renal function. Prevailing dogma in PKD is that changes in kidney architecture account for the decline in kidney function, but the molecular/cellular basis of such coupling is u...

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Literature Corpus work: 617931a8-09a9-5692-a813-a94f21aa06aa
DOI: 10.1101/2024.02.29.582788

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