Article

Loss of ADAMTS9 disrupts ciliogenesis and collagen homeostasis resulting in Nephronophthisis-like polycystic kidneys

2025-12-03

Abstract excerpt

<h4>ABSTRACT</h4> ADAMTS9 mutations cause the ciliopathies nephronophthisis and Joubert syndrome. Here we show that deletion of ADAMTS9 in the proximal nephron leads to polycystic kidney development in mice. In males, Adamts9 deletion cause kidneys to become highly cystic but remain small without undergoing enlargement, causing early postnatal lethality. Female mice on the other hand, develop cystic kidneys but...

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Literature Corpus work: c8902f47-7535-5656-a477-73db3f6d1252
DOI: 10.64898/2025.12.02.691883

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