Article

Aberrant centrosome biogenesis disrupts nephron progenitor cell renewal and fate resulting in fibrocystic kidney disease

2023-04-05

Abstract excerpt

<h4>Summary</h4> Mutations that disrupt centrosome structure or function cause congenital kidney developmental defects and fibrocystic pathologies. Yet, it remains unclear how mutations in proteins essential for centrosome biogenesis impact embryonic kidney development. Here, we examined the consequences of conditional deletion of a ciliopathy gene, Cep120 , in the two nephron progenitor niches of the embryonic...

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Literature Corpus work: e72ae832-2e68-58dd-9b2d-15d14a40396f
DOI: 10.1101/2023.04.04.535568

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