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Inactivation of <i>Nphp2</i> in renal epithelial cells drives infantile nephronophthisis like phenotypes in mouse

2022-02-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Nephronophthisis (NPHP) is a ciliopathy characterized by renal fibrosis and cyst formation, and accounts for a significant portion of end stage renal disease in children and young adults. Currently no targeted therapy is available for this disease. NPHP2 is one of the 25 NPHP genes identified to date. In mouse, global knockout of Nphp2 leads to renal fibrosis and cysts. Ho...

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Literature Corpus work
c2533cc8-2b8f-5c8b-992a-d18efb1b8b71
DOI
10.1101/2022.02.10.479981
Open publication

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