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Article

Transcription factor 21 deletion from podocyte precursors as a model for congenital nephrotic syndrome.

American journal of physiology. Renal physiology - 1 Jun 2026

Dalal Vidhi, Zhou Yalu, Deb Dilip K, Thomson Benjamin R, Nelson Jonathan W, Ledogar Grace, Misener Sol, Maekawa Hiroshi, Chang Anthony, Chung Eunah, Park Joo-Seop, Quaggin Susan E

Abstract excerpt

Nephrotic syndrome is one of the most common causes of kidney disease in children. The glomerular and tubulointerstitial changes that occur in the kidney due to this state of high-grade proteinuria are incompletely understood. Here, we report a mouse model of congenital nephrotic syndrome, induced by deletion of transcription factor 21 (Tcf21) from podocyte precursors, that can be used to study the injury...

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Source

Identifiers

PMID: 42090190
DOI: 10.1152/ajprenal.00490.2025

Genes

TCF21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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