Article

Developmental switch dichotomizes kidney response to <i>Nphp3</i> inactivation and treatment outcome

2026-05-26

Abstract excerpt

<h4>ABSTRACT</h4> Nephronophthisis (NPH) is n rare recessive kidney disease caused by biallelic variants in more than 25 NPHP genes encoding proteins that localize to primary cilia. It is characterized by three different forms depending on the age of onset and kidney lesions: infantile (cystic), juvenile/late onset (fibrotic). To date, the pathways linking altered primary cilia function to progressive kidney sca...

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Literature Corpus work: 91d55231-bbca-5ecd-92d6-2d61706cce8e
DOI: 10.64898/2026.05.21.726570

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