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Article

LILRB1 and LILRB2 genomics and transcriptomics in macaque and baboon species: polymorphism, diversification, and extensive alternative splicing.

Frontiers in immunology - 1 Jan 2025

de Groot Natasja G, de Groot Nanine, Heijmans Corrine M C, de Vos-Rouweler Annemiek J M, van der Wiel Marit K H, Bruijnesteijn Jesse

Abstract excerpt

Introduction: Inhibitory receptors play a pivotal role in fine-tuning immune responses. The leukocyte receptor complex (LRC) encodes multiple receptor families, including the leukocyte immunoglobulin-like receptor (LILR) family, which next to activating receptors involves several inhibitory receptors. The LILRB1 and LILRB2 receptors are considered immune checkpoint inhibitors, which may interact with MHC class I...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41583460
DOI: 10.3389/fimmu.2025.1706720
PMCID: PMC12827074

Genes

LILRB1
LILRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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