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Article

Copy number and nucleotide variation of the LILR family of myelomonocytic cell activating and inhibitory receptors.

Immunogenetics - 1 Feb 2014

López-Álvarez María R, Jones Des C, Jiang Wei, Traherne James A, Trowsdale John

Abstract excerpt

Leukocyte immunoglobulin-like receptors (LILR) are cell surface molecules that regulate the activities of myelomonocytic cells through the balance of inhibitory and activation signals. LILR genes are located within the leukocyte receptor complex (LRC) on chromosome 19q13.4 adjacent to KIR genes, which are subject to allelic and copy number variation (CNV). LILRB3 (ILT5) and LILRA6 (ILT8) are highly polymorphic...

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Topics

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Share to Amino Acid Motifs
Share to Antigens, CD
Share to Chromosomes, Human, Pair 19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to Gene Duplication

Share to Monocytes

Share to Receptors, Immunologic

Share to Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 24257760
DOI: 10.1007/s00251-013-0742-5
PMCID: PMC3894450

Genes

LILRA6
LILRB3
LILRA3

Provenance

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