Article

Chronological Age Reshapes the Molecular Landscape of Polygenic Risk Across the Human Lifespan

2026-04-30

Abstract excerpt

<title>Abstract</title> <p>An individual’s polygenic risk is fixed at conception, yet those pathological consequences manifest dynamically over the lifespan. The molecular mechanisms through which chronological age reshapes static genetic risk into late-onset disease remain largely unknown, obscured by the inability of conventional linear methods to model complex, non-linear interactions in high-dimensional multi...

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Literature Corpus work: d758e446-0e64-5022-8714-b021ebd72e6e
DOI: 10.21203/rs.3.rs-9418894/v1

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