Article

Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution

2021-11-30

Abstract excerpt

NAT10 is an essential enzyme that catalyzes the formation of N 4 -acetylcytidine (ac 4 C) in eukaryotic transfer RNA (tRNA) and 18S ribosomal RNA (rRNA). Recent studies in human cells suggested that rRNA acetylation is dependent on SNORD13, a non-canonical box C/D small nucleolar RNA (SNORD) predicted to base-pair with 18S rRNA via two antisense elements. However, the selectivity of SNORD13-dependent cytidine ac...

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Literature Corpus work: 6137ac83-243a-5df5-908c-907917e988f6
DOI: 10.1101/2021.11.30.470322

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