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Article

Activity reconstitution of Kre33 and Tan1 reveals a molecular ruler mechanism in eukaryotic tRNA acetylation.

Nucleic acids research - 22 May 2024

Ma Chun-Rui, Liu Na, Li Hong, Xu Hong, Zhou Xiao-Long

Abstract excerpt

RNA acetylation is a universal post-transcriptional modification that occurs in various RNAs. Transfer RNA (tRNA) acetylation is found at position 34 (ac4C34) in bacterial tRNAMet and position 12 (ac4C12) in eukaryotic tRNASer and tRNALeu. The biochemical mechanism, structural basis and functional significance of ac4C34 are well understood; however, despite being discovered in the 1960s and identification of...

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Share to Acetylation
Share to Acetyltransferases
Share to Nucleic Acid Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA-Binding Proteins

Share to RNA Processing, Post-Transcriptional

Share to RNA, Transfer

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Source

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Identifiers

PMID: 38613394
DOI: 10.1093/nar/gkae262
PMCID: PMC11109946

Genes

NAT10
THUMPD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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