Back to search

Article

PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

2020-05-16

Abstract excerpt

Precision medicine in oncology leverages clinical observations of exceptional response. Towards an understanding of the molecular features that define this response, we applied an integrated, multi-platform analysis of RNA profiles derived from clinically annotated glioblastoma samples. This analysis suggested that specimens from exceptional responders are characterized by decreased accumulation of microglia/macro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
612529dd-838d-5515-af69-3cfd9a1c930e
DOI
10.1101/2020.05.14.097121
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide responseDOI 10.1101/2020.05.14.097121
PI3K signaling promotes inflammatory tumor-macrophage crosstalk associated with mesenchymal glioblastomaSemantic proximity
Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenograftsSemantic proximity
Molecular biology of the deadliest cancer – glioblastoma: what do we know?Semantic proximity
Single-Cell Transcriptomics Uncover IBSP as a Mediator of Tumor-Associated Microglia and Macrophages-Driven Glioblastoma ProgressionSemantic proximity
Progenitor Cells, Microglia, and Non-coding RNAs: Orchestrators of Glioblastoma Pathogenesis and Therapeutic ResistanceSemantic proximity
Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in GlioblastomaSemantic proximity
Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts.Semantic proximity
Pro-inflammatory and proliferative microglia drive progression of glioblastoma.Semantic proximity
Spatially resolved single-cell analysis uncovers protein kinase Cδ-expressing microglia with anti-tumor activity in glioblastomaSemantic proximity
Single-Cell Transcriptomics of Glioblastoma Reveals a Unique Tumor Microenvironment and Potential Immunotherapeutic Target Against Tumor-Associated MacrophageSemantic proximity
Glioblastoma hijacks microglial gene expression to support tumor growthSemantic proximity
Single-cell transcriptome-based multilayer network biomarker for predicting prognosis and therapeutic response of gliomasSemantic proximity
Select a neighboring publication to make it the new centre.