Article
EZH2 mutations are frequent and represent an early event in follicular lymphoma.
Blood - 31 Oct 2013
Bödör Csaba, Grossmann Vera, Popov Nikolay, Okosun Jessica, O'Riain Ciarán, Tan King, Marzec Jacek, Araf Shamzah, Wang Jun, Lee Abigail M, Clear Andrew, Montoto Silvia, Matthews Janet, Iqbal Sameena, Rajnai Hajnalka, Rosenwald Andreas, Ott German, Campo Elias, Rimsza Lisa M, Smeland Erlend B, Chan Wing C, Braziel Rita M, Staudt Louis M, Wright George, Lister T Andrew, Elemento Olivier, Hills Robert, Gribben John G, Chelala Claude, Matolcsy András, Kohlmann Alexander, Haferlach Torsten, Gascoyne Randy D, Fitzgibbon Jude
Abstract excerpt
Gain of function mutations in the H3K27 methyltransferase EZH2 represent a promising therapeutic target in germinal center lymphomas. In this study, we assessed the frequency and distribution of EZH2 mutations in a large cohort of patients with follicular lymphoma (FL) (n = 366) and performed a longitudinal analysis of mutation during the disease progression from FL to transformed FL (tFL) (n = 33). Mutations...
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