Article
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.
Nature genetics - 1 Feb 2010
Morin Ryan D, Johnson Nathalie A, Severson Tesa M, Mungall Andrew J, An Jianghong, Goya Rodrigo, Paul Jessica E, Boyle Merrill, Woolcock Bruce W, Kuchenbauer Florian, Yap Damian, Humphries R Keith, Griffith Obi L, Shah Sohrab, Zhu Henry, Kimbara Michelle, Shashkin Pavel, Charlot Jean F, Tcherpakov Marianna, Corbett Richard, Tam Angela, Varhol Richard, Smailus Duane, Moksa Michelle, Zhao Yongjun, Delaney Allen, Qian Hong, Birol Inanc, Schein Jacqueline, Moore Richard, Holt Robert, Horsman Doug E, Connors Joseph M, Jones Steven, Aparicio Samuel, Hirst Martin, Gascoyne Randy D, Marra Marco A
Abstract excerpt
Follicular lymphoma (FL) and the GCB subtype of diffuse large B-cell lymphoma (DLBCL) derive from germinal center B cells. Targeted resequencing studies have revealed mutations in various genes encoding proteins in the NF-kappaB pathway that contribute to the activated B-cell (ABC) DLBCL subtype, but thus far few GCB-specific mutations have been identified. Here we report recurrent somatic mutations affecting the...
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