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Article

Comparative Analysis of the Clinicopathological Features of Follicular Lymphoma With and Without EZH2 Y646 Mutation.

Pathology international - 1 Aug 2026

Satou Akira, Yoshikawa Kanae, Mitsuda Ikki, Iwakoshi Akari, Minoshima Makoto, Gunji Masaharu, Murakami Hideki, Carreras Joaquim, Ikoma Haruka, Nakamura Naoya, Tsuzuki Toyonori, Sato Masanori, Karube Kennosuke

Abstract excerpt

Histone methyltransferase EZH2 is essential for germinal center formation, and gain-of-function mutations of EZH2 occur in approximately 20% of follicular lymphomas (FLs). Although EZH2 inhibitors are used for relapsed/refractory EZH2-mutated (EZH2mut) FLs, their clinicopathological characteristics remain incompletely understood. We assessed the EZH2 Y646 mutation by Sanger sequencing in 301 FLs and identified...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42633616
DOI: 10.1111/pin.70167
PMCID: PMC13500034

Genes

BCL2
BCL6
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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